1 November 2007 Clinical evaluation of time-resolved spectroscopy by measuring cerebral hemodynamics during cardiopulmonary bypass surgery
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J. of Biomedical Optics, 12(6), 062112 (2007). doi:10.1117/1.2804931
Abstract
We developed a three-wavelength time-resolved spectroscopy (TRS) system, which allows quantitative measurement of hemodynamics within relatively large living tissue. We clinically evaluated this TRS system by monitoring cerebral circulation during cardiopulmonary bypass surgery. Oxyhemoglobin, deoxyhemoglobin, total hemoglobin and oxygen saturation (SO2) were determined by TRS on the left forehead attached with an optode spacing of 4 cm. We also simultaneously monitored jugular venous oxygen saturation (SjvO2) and arterial blood hematocrit (Hct) using conventional methods. The validity and usefulness of the TRS system were assessed by comparing parameters obtained with the TRS and conventional methods. Although the changes in SO2 were lower than those in SjvO2, SO2 obtained by TRS paralleled the fluctuations in SjvO2, and a good correlation between these values was observed. The only exceptions occurred during the perfusion period. Moreover, there was a good correlation between tHb and Hct values (r2=0.63). We concluded that time-resolved spectroscopy reflected the conditions of cerebral hemodynamics of patients during surgical operations.
Etsuko Ohmae, Motoki Oda, Toshihiko Suzuki, Yutaka Yamashita, Yasuyuki Kakihana, Akira Matsunaga, Yuichi Kanmura, Mamoru Tamura, "Clinical evaluation of time-resolved spectroscopy by measuring cerebral hemodynamics during cardiopulmonary bypass surgery," Journal of Biomedical Optics 12(6), 062112 (1 November 2007). https://doi.org/10.1117/1.2804931
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