Optoacoustic imaging based on the interferometric measurement of surface displacement

Stefan A. Carp; Vasan Venugopalan

doi:10.1117/1.2812665

Abstract

We present images of tissue phantoms and chicken chorio-allantoic membrane vasculature using a novel optoacoustic tomography technique based on the time-resolved interferometric measurement of laser-induced thermoelastic expansion. Our imaging system is based on a modified Mach-Zehnder interferometer that provides surface displacement measurements with a temporal resolution of 4 ns and a displacement sensitivity of 0.3 nm. The images are reconstructed from surface displacement measurements made at several locations following irradiation of the sample with Q-switched Nd:YAG (λ=532, 1064 nm) laser pulses using a delay and sum beam-forming algorithm. The images shown demonstrate the ability of our method to provide better than 200-μm lateral and 30-μm axial resolution at depths exceeding ten transport mean free paths in highly scattering in-vitro and in-vivo model systems.

Citation Download Citation

Stefan A. Carp, Stefan A. Carp, Vasan Venugopalan, Vasan Venugopalan, } "Optoacoustic imaging based on the interferometric measurement of surface displacement," Journal of Biomedical Optics 12(6), 064001 (1 November 2007). https://doi.org/10.1117/1.2812665 . Submission:

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