1 November 2007 Core-shell silica nanoparticles as fluorescent labels for nanomedicine
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Progress in biomedical imaging depends on the development of probes that combine low toxicity with high sensitivity, resolution, and stability. Toward that end, a new class of highly fluorescent core-shell silica nanoparticles with narrow size distributions and enhanced photostability, known as C dots, provide an appealing alternative to quantum dots. Here, C dots are evaluated with a particular emphasis on in-vivo applications in cancer biology. It is established that C dots are nontoxic at biologically relevant concentrations, and can be used in a broad range of imaging applications including intravital visualization of capillaries and macrophages, sentinel lymph node mapping, and peptide-mediated multicolor cell labeling for real-time imaging of tumor metastasis and tracking of injected bone marrow cells in mice. These results demonstrate that fluorescent core-shell silica nanoparticles represent a powerful novel imaging tool within the emerging field of nanomedicine.
© (2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
Jinhyang Choi, Jinhyang Choi, Andrew A. Burns, Andrew A. Burns, Rebecca M. Williams, Rebecca M. Williams, Zongziang Zhou, Zongziang Zhou, Andrea Flesken-Nikitin, Andrea Flesken-Nikitin, Warren R. Zipfel, Warren R. Zipfel, Ulrich Wiesner, Ulrich Wiesner, Alexander Yu Nikitin, Alexander Yu Nikitin, } "Core-shell silica nanoparticles as fluorescent labels for nanomedicine," Journal of Biomedical Optics 12(6), 064007 (1 November 2007). https://doi.org/10.1117/1.2823149 . Submission:

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