1 January 2008 In vivo optical imaging of CD13/APN-expression in tumor xenografts
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Abstract
The metalloexopeptidase CD13/aminopeptidase N (APN) has been shown to be involved in cancer angiogenesis, invasion, and metastasis. Therefore, a CD13/APN–targeted In vivo, tumor xenografts (n≥5) were clearly visualized by two-dimensional (2-D) planar fluorescence reflectance imaging (FRI) and three-dimensional (3-D) fluorescence mediated tomography (FMT) up to 24 h after injection. FMT also allowed us to quantify fluorochrome distribution in deeper tissue sections, showing an average fluorochrome concentration of 306.7±54.3 nM Cy 5.5 (HT-1080) and 116.0±18.3 nM Cy 5.5 (MCF-7) in the target tissue after 5 h. Competition with the free in vivo.
© (2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
Angelika von Wallbrunn, Angelika von Wallbrunn, Jens Waldeck, Jens Waldeck, Carsten Hoeltke, Carsten Hoeltke, Michael Zühlsdorf, Michael Zühlsdorf, Rolf Mesters, Rolf Mesters, Walter L. Heindel, Walter L. Heindel, Michael Schäfers, Michael Schäfers, Christoph Bremer, Christoph Bremer, } "In vivo optical imaging of CD13/APN-expression in tumor xenografts," Journal of Biomedical Optics 13(1), 011007 (1 January 2008). https://doi.org/10.1117/1.2839046 . Submission:
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