1 January 2008 In vivo optical imaging of CD13/APN-expression in tumor xenografts
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J. of Biomedical Optics, 13(1), 011007 (2008). doi:10.1117/1.2839046
The metalloexopeptidase CD13/aminopeptidase N (APN) has been shown to be involved in cancer angiogenesis, invasion, and metastasis. Therefore, a CD13/APN–targeted In vivo, tumor xenografts (n≥5) were clearly visualized by two-dimensional (2-D) planar fluorescence reflectance imaging (FRI) and three-dimensional (3-D) fluorescence mediated tomography (FMT) up to 24 h after injection. FMT also allowed us to quantify fluorochrome distribution in deeper tissue sections, showing an average fluorochrome concentration of 306.7±54.3 nM Cy 5.5 (HT-1080) and 116.0±18.3 nM Cy 5.5 (MCF-7) in the target tissue after 5 h. Competition with the free in vivo.
Angelika von Wallbrunn, Jens Waldeck, Carsten Hoeltke, Michael Zühlsdorf, Rolf Mesters, Walter L. Heindel, Michael Schäfers, Christoph Bremer, "In vivo optical imaging of CD13/APN-expression in tumor xenografts," Journal of Biomedical Optics 13(1), 011007 (1 January 2008). https://doi.org/10.1117/1.2839046

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