1 January 2008 In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography
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Abstract
We present in vivo experiments conducted with a new fluorescence diffuse optical tomographic (fDOT) system on cancerous mice bearing mammary murine tumors. We first briefly present this new system that has been developed and its associated reconstruction method. Its main specificity is its ability to reconstruct the fluorescence yield even in heterogeneous and highly attenuating body regions such as lungs and to enable mouse inspection without immersion in optical index matching liquid (Intralipid and ink). Some phantom experiments validate the performance of this new system for heterogeneous media inspection. Its use for a mice study is then related. It consists in the follow-up of the lungs at different stages of tumor development after injection of RAFT-(cRGD)4-Alexa700. As expected, the reconstructed fluorescence increases along with the tumor stage. These results validate the use of our system for biological studies of small animals.
© (2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
Anne Koeing, Anne Koeing, Lionel Herve, Lionel Herve, Véronique Josserand, Véronique Josserand, Michel Berger, Michel Berger, Jérôme Boutet, Jérôme Boutet, Anabela Da Silva, Anabela Da Silva, Jean-Marc Dinten, Jean-Marc Dinten, Philippe Peltie, Philippe Peltie, Jean-Luc Coll, Jean-Luc Coll, Philippe Rizo, Philippe Rizo, } "In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography," Journal of Biomedical Optics 13(1), 011008 (1 January 2008). https://doi.org/10.1117/1.2884505 . Submission:
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