1 March 2008 Application of optical coherence tomography, pulsed photoacoustic technique, and time-of-flight technique to detect changes in the scattering properties of a tissue-simulating phantom
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J. of Biomedical Optics, 13(2), 024005 (2008). doi:10.1117/1.2899152
Abstract
Intralipid is a well-known emulsion used as a tissue-simulating phantom in developing optical imaging and diagnostic techniques for medical applications. The optical coherence tomography (OCT), pulsed photoacoustic (PA), and time-of-flight (TOF) techniques were used to detect glucose-induced changes in the optical properties of Intralipid. A comparison of the applicability of these techniques to register changes in the scattering properties of Intralipid samples showed that OCT is the most effective method, whereas the sensitivity of the PA technique was less pronounced. Photon migration studies with the TOF technique showed changes in pulse amplitude, pulse width, and arrival time of the pulse maximum as a function of changes in Intralipid concentration. Also the measured signal parameters showed changes when measuring high glucose concentrations.
Matti T. Kinnunen, Risto A. Myllylä, "Application of optical coherence tomography, pulsed photoacoustic technique, and time-of-flight technique to detect changes in the scattering properties of a tissue-simulating phantom," Journal of Biomedical Optics 13(2), 024005 (1 March 2008). http://dx.doi.org/10.1117/1.2899152
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KEYWORDS
Optical coherence tomography

Glucose

Scattering

Photoacoustic spectroscopy

Pulsed laser operation

Tissue optics

Laser scattering

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