Pulsed diode laser-based monitor for singlet molecular oxygen

Seonkyung Lee; Leyun Zhu; Ahmed M. Minhaj; Michael F. Hinds; Danthu H. Vu; David I. Rosen; Steven J. Davis; Tayyaba Hasan

doi:10.1117/1.2927465

1 May 2008 Pulsed diode laser-based monitor for singlet molecular oxygen

Seonkyung Lee; Leyun Zhu; Ahmed M. Minhaj; Michael F. Hinds; Danthu H. Vu; David I. Rosen; Steven J. Davis; Tayyaba Hasan

Author Affiliations +

J. of Biomedical Optics, 13(3), 034010 (2008). https://doi.org/10.1117/1.2927465

Abstract

Photodynamic therapy (PDT) is a promising cancer treatment. PDT uses the affinity of photosensitizers to be selectively retained in malignant tumors. When tumors, pretreated with the photosensitizer, are irradiated with visible light, a photochemical reaction occurs and tumor cells are destroyed. Oxygen molecules in the metastable singlet delta state O₂(¹Δ) are believed to be the species that destroys cancerous cells during PDT. Monitoring singlet oxygen produced by PDT may lead to more precise and effective PDT treatments. Our approach uses a pulsed diode laser-based monitor with optical fibers and a fast data acquisition system to monitor singlet oxygen during PDT. We present results of in vitro singlet oxygen detection in solutions and in a rat prostate cancer cell line as well as PDT mechanism modeling.

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Seonkyung Lee, Seonkyung Lee, Leyun Zhu, Leyun Zhu, Ahmed M. Minhaj, Ahmed M. Minhaj, Michael F. Hinds, Michael F. Hinds, Danthu H. Vu, Danthu H. Vu, David I. Rosen, David I. Rosen, Steven J. Davis, Steven J. Davis, Tayyaba Hasan, Tayyaba Hasan, } "Pulsed diode laser-based monitor for singlet molecular oxygen," Journal of Biomedical Optics 13(3), 034010 (1 May 2008). https://doi.org/10.1117/1.2927465 . Submission:

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