1 September 2008 Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography
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Abstract
We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand white rabbits injected with monocrystalline iron oxide nanoparticles (MIONs) of <40 nm diam. MIONs taken up by macrophages was excited by an oscillating magnetic flux density and resulting nanometer tissue surface displacement was detected by DP-OCT. Frequency response of tissue surface displacement in response to an externally applied magnetic flux density was twice the stimulus frequency as expected from the equations of motion for the nanoparticle cluster.
Junghwan Oh, Marc D. Feldman, H. Golombek, Jihoon Kim, Pramod Sanghi, Dat Do, J. Jacob Mancuso, Nathaniel Joseph Kemp, Mehmet Cilingiroglu, Thomas E. Milner, "Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography," Journal of Biomedical Optics 13(5), 054006 (1 September 2008). https://doi.org/10.1117/1.2985762
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