Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo

Bing Yu; Justin Y. Lo; Thomas F. Kuech; Gregory M. Palmer; Janelle Elise Bender; Nirmala Ramanujam

doi:10.1117/1.3041500

1 November 2008 Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo

Bing Yu, Justin Y. Lo, Thomas F. Kuech, Gregory M. Palmer, Janelle Elise Bender, Nirmala Ramanujam

Author Affiliations +

Journal of Biomedical Optics, Vol. 13, Issue 6, 060505 (November 2008). https://doi.org/10.1117/1.3041500

Abstract

A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0±5.6 and 6.1±4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Bing Yu, Justin Y. Lo, Thomas F. Kuech, Gregory M. Palmer, Janelle Elise Bender, and Nirmala Ramanujam "Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo," Journal of Biomedical Optics 13(6), 060505 (1 November 2008). https://doi.org/10.1117/1.3041500

Published: 1 November 2008

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KEYWORDS

Tissue optics

Scattering

Absorption

Photodiodes

Optical properties

Tissues

Imaging spectroscopy

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