Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging

Zhen Wang; Weihua Luo; Pengcheng Li; Jianjun Qiu; Qingming Luo

doi:10.1117/1.3041710

1 November 2008 Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging

Zhen Wang, Weihua Luo, Pengcheng Li, Jianjun Qiu, Qingming Luo

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Journal of Biomedical Optics, Vol. 13, Issue 6, 064023 (November 2008). https://doi.org/10.1117/1.3041710

Abstract

Hyperglycemia and cortical spreading depression (CSD) are possible factors that worsen the outcome of ischemic stroke, and it is probable that there is a longterm cooperative effect of hyperglycemia and CSD on cerebral blood flow (CBF). Long-lasting and full-field observation of changes in CBF following CSD in vivo during acute hyperglycemia in rats might show whether this is the case. Here, we utilized laser speckle imaging to study influences of acute hyperglycemia on CBF at the level of individual vascular compartments for 3 h in normal rats and those with CSD. It is shown that there are extensive increases of CBF at the arteriole and parenchyma over the normal rat cortex during acute hyperglycemia, whereas there is no significant change in CBF at the venule. We also find that, at all vascular compartments, after the glucose administration there is a stepwise reduction of CBF following CSD, but after saline injection CBF following CSD is close to the baseline. Our results indicate that acute hyperglycemia could aggravate the severity of decrease in CBF following CSD, suggesting possible mechanisms by which hyperglycemia exacerbates cerebral damage after ischemic stroke.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Zhen Wang, Weihua Luo, Pengcheng Li, Jianjun Qiu, and Qingming Luo "Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging," Journal of Biomedical Optics 13(6), 064023 (1 November 2008). https://doi.org/10.1117/1.3041710

Published: 1 November 2008

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