1 July 2009 Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo
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J. of Biomedical Optics, 14(4), 040505 (2009). doi:10.1117/1.3207121
Abstract
Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mouse brain upon traumatic brain injury (TBI), with the cranium left intact, for a period of two weeks on the same animal. We show the ability of OMAG to repeatedly image 3-D cerebral vasculatures during pre- and post-traumatic phases, and to visualize the changes of regulated CBF and the vascular plasticity after TBI. The results indicate the potential of OMAG to explore the mechanism involved in the rehabilitation of TBI.
Yali Jia, Nabil J. Alkayed, Ruikang K. Wang, "Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo," Journal of Biomedical Optics 14(4), 040505 (1 July 2009). http://dx.doi.org/10.1117/1.3207121
Submission: Received ; Accepted
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KEYWORDS
Traumatic brain injury

Blood

Blood circulation

In vivo imaging

Brain

Tissue optics

Image resolution

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