1 January 2009 Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy
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One of the problems of near-infrared-spectroscopy (NIRS) measurements is low reproducibility. The aim of the present study was to introduce quality criteria to increase reproducibility of peripheral NIRS measurements. In a prospective cohort study in 40 neonates, repeated NIRS measurements were performed on the calf. During five "reapplication" periods (of NIRS optodes), five "measurements" (venous occlusions) were performed. Tissue oxygenation index (TOI), mixed venous oxygenation (SvO2), fractional oxygen extraction (FOE), hemoglobin flow (Hbflow), oxygen delivery (DO2), and oxygen consumption (VO2) were assessed. Measurements with linear changes during venous occlusions were included for further analysis (first quality criterion: R2>0.95). The second quality criterion was the equation 0 ≤ TOI-SvO2 ≤(SaO2-SvO2)×0.2. Variance components and mean standard deviations were analyzed after introduction of the quality criteria. Variance components of reapplication and measurement decreased after introduction of the second quality criterion (TOI: 46.6–35.0%, SvO2: 76.8–38.2%, FOE: 73.1–37.5%, Hbflow: 70.3–51.9%, DO2: 71.5–52.7%, and VO2: 70.9–63.8%). Mean standard deviations of TOI (6.6±3.0 to 4.7±3.2%), SvO2 (11.1±4.8 to 5.7±3.9%), FOE (11.3±4.8 to 5.9±4.0%), Hbflow (4.3±2.0 to 2.9±1.6 μmol/100 mL/min), and DO2 (17.8±7.6 to 11.4±6.2 μmol/100 mL/min) decreased significantly, too. Only 12% of measurements fulfilled both quality criteria. With the introduction of two quality criteria, test–retest variability of peripheral NIRS measurements decreased significantly and reproducibility increased significantly.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Gerhard Pichler, Gerhard Pichler, Karin Grossauer, Karin Grossauer, Elisabeth Peichl, Elisabeth Peichl, Andrea Gaster, Andrea Gaster, Andrea Berghold, Andrea Berghold, Gerold Schwantzer, Gerold Schwantzer, Heinz Zotter, Heinz Zotter, William Müller, William Müller, Berndt Urlesberger, Berndt Urlesberger, } "Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy," Journal of Biomedical Optics 14(1), 014014 (1 January 2009). https://doi.org/10.1117/1.3076193 . Submission:

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