Dynamic topographic mapping of the human bladder during voiding using functional near-infrared spectroscopy

Andrew J. Macnab M.D.; Lynn Stothers M.D.; Babak Shadgan M.D.

doi:10.1117/1.3122886

1 March 2009 Dynamic topographic mapping of the human bladder during voiding using functional near-infrared spectroscopy

Andrew J. Macnab M.D., Lynn Stothers M.D., Babak Shadgan M.D.

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 2, 020507 (March 2009). https://doi.org/10.1117/1.3122886

Abstract

Functional near-infrared spectroscopy (fNIRS) with multichannel instruments and grids of source-detector pairs can map regional change in oxygenation/hemodynamics. Developed for cortical brain mapping, fNIRS technology has relevance in other organs where pathology affects the microcirculation. We describe fNIRS of the human bladder for evaluation of hemodynamic change during voiding. A 5×5-cm grid with two source-detector pairs is placed on the abdomen suprapubically in an asymptomatic male. In four separate trials, after natural bladder filling NIRS-derived changes in oxyhemoglobin (O₂Hb), deoxyhemoglobin (HHb), and total hemoglobin (tHb) concentration are recorded during voiding (measured via uroflow), using four channels of a four wavelength continuous wave instrument. Graphic and video images (topographic mapping software) are generated. Changes in tHb occur following permission to void that predominantly reflected variation in O₂Hb; tHb peaks at maximum urine flow then falls to a nadir lasting to uroflow end. Change in fNIRS video color intensity correlates with graphic change in chromophore concentration. Color variations across the mapped area suggest regional hemodynamic variation. fNIRS bladder studies generate reproducible chromophore data consistent with single channel studies, but the dynamic color video and larger tissue area monitored potentially offer new methodology for investigating regional variations in bladder oxygenation and hemodynamics.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Andrew J. Macnab M.D., Lynn Stothers M.D., and Babak Shadgan M.D. "Dynamic topographic mapping of the human bladder during voiding using functional near-infrared spectroscopy," Journal of Biomedical Optics 14(2), 020507 (1 March 2009). https://doi.org/10.1117/1.3122886

Published: 1 March 2009

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 11 scholarly publications.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Bladder

Near infrared spectroscopy

Hemodynamics

Video

Chromophores

Visualization

Pathology

Show All Keywords

RELATED CONTENT

Simultaneous functional near infrared spectroscopy of the brain and bladder
Proceedings of SPIE (February 21 2020)

Spatial frequency domain imaging of hemodynamic parameters in a murine...
Proceedings of SPIE (February 25 2020)

Optical diagnosis of interstitial cystitis / painful bladder syndrome
Proceedings of SPIE (March 14 2013)

Near infrared spectroscopy of the bladder a new technique...
Proceedings of SPIE (March 02 2010)

Monitoring of lower urinary tract function in patients with spinal...
Proceedings of SPIE (February 09 2012)

Home based monitoring of lower urinary tract health simultaneous...
Proceedings of SPIE (March 02 2022)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years