1 March 2009 Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging
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Abstract
Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1064 nm, maximum power 1 W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Alexandru S. Biris, Dorin Boldor, Jason Palmer, William Todd Monroe, Meena Mahmood, Enkeleda Dervishi, Yang Xu, Zhongrui Li, Ekaterina I. Galanzha, Vladimir P. Zharov, "Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging," Journal of Biomedical Optics 14(2), 021007 (1 March 2009). https://doi.org/10.1117/1.3119135 . Submission:
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