1 March 2009 Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels
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Abstract
Accurate blood flow measurements during surgery can improve an operation's chance of success. We developed near-infrared spatio-temporal image spectroscopy (NIR-STICS), which has the potential to make blood flow measurements that are difficult to accomplish with existing methods. Specifically, we propose the technique and we show feasibility on phantom measurements. NIR-STICS has the potential of measuring the fluid velocity in small blood vessels (less than 1 mm in diameter) and of creating a map of blood flow rates over an area of approximately 1 cm2. NIR-STICS employs near-infrared spectroscopy to probe inside blood vessel walls and spatiotemporal image correlation spectroscopy to directly-without the use of a model-extract fluid velocity from the fluctuations within an image. We present computer simulations and experiments on a phantom system that demonstrate the effectiveness of NIR-STICS.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Molly J. Rossow, William W. Mantulin, Enrico Gratton, "Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels," Journal of Biomedical Optics 14(2), 024014 (1 March 2009). https://doi.org/10.1117/1.3088203 . Submission:
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