1 May 2009 Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles
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Abstract
Contrast in optical coherence tomography (OCT) images can be enhanced by utilizing surface plasmon resonant gold nanoparticles. To improve the poor in vivo transport of gold nanoparticles through biological barriers, an efficient delivery strategy is needed. In this study, the improved penetration and distribution of gold nanoparticles were achieved by microneedle and ultrasound, respectively, and it was demonstrated that this multimodal delivery of antibody-conjugated PEGylated gold nanoparticles enhanced the contrast in in vivo OCT images of oral dysplasia in a hamster model.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Chang Soo Kim, Petra B. B. Wilder-Smith, Yeh-Chan Ahn, Lih-Huei L. Liaw, Zhongping Chen, Young Jik Kwon, "Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles," Journal of Biomedical Optics 14(3), 034008 (1 May 2009). https://doi.org/10.1117/1.3130323 . Submission:
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