1 May 2009 Multimodality bonchoscopic imaging of tracheopathica osteochondroplastica
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J. of Biomedical Optics, 14(3), 034035 (2009). doi:10.1117/1.3155524
Results of a commercial optical coherence tomography system used as part of a multimodality diagnostic bronchoscopy platform are presented for a 61-year-old patient with central airway obstruction from tracheopathica osteochondroplastica. Comparison to results of white-light bronchoscopy, histology, and endobronchial ultrasound examination are accompanied by a discussion of resolution, penetration depth, contrast, and field of view of these imaging modalities. White-light bronchoscopy revealed irregularly shaped, firm submucosal nodules along cartilaginous structures of the anterior and lateral walls of the trachea, sparing the muscular posterior membrane. Endobronchial ultrasound showed a hyperechoic density of 0.4 cm thickness. optical coherence tomography (OCT) was performed using a commercially available, compact time-domain OCT system (Niris System, Imalux Corp., Cleveland, Ohio) with a magnetically actuating probe (two-dimensional, front imaging, and inside actuation). Images showed epithelium, upper submucosa, and osseous submucosal nodule layers corresponding with histopathology. To our knowledge, this is the first time these commercially available systems are used as part of a multimodality bronchoscopy platform to study diagnostic imaging of a benign disease causing central airway obstruction. Further studies are needed to optimize these systems for pulmonary applications and to determine how new-generation imaging modalities will be integrated into a multimodality bronchoscopy platform.
Henri G. Colt, Septimiu Dan Murgu, Yeh-Chan Ahn, Matthew Brenner, "Multimodality bonchoscopic imaging of tracheopathica osteochondroplastica," Journal of Biomedical Optics 14(3), 034035 (1 May 2009). https://doi.org/10.1117/1.3155524

Imaging systems

Optical coherence tomography



Image resolution



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