1 July 2009 Infrared-based third and second harmonic generation imaging of cornea
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The cornea functions as an optical lens and plays an important role in vision. For corneal diagnosis and treatment such as refractive surgery, a microscopic imaging system with a 3-D cellular resolution and retinal safety is strongly desired. Recently, confocal and multiphoton microscopies have been applied to corneal imaging with visible to near-infrared light sources. To increase retinal safety, an infrared light source is be needed. In this work, an infrared-based third and second harmonic generation microscopic study of mouse eyes is reported with ~700-μm penetrability and high cellular resolution. This study provides a critical reference for future development of infrared-based corneal imaging.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Szu-Yu Chen, Szu-Yu Chen, Han-Chieh Yu, Han-Chieh Yu, I-Jong Wang, I-Jong Wang, Chi-Kuang Sun, Chi-Kuang Sun, } "Infrared-based third and second harmonic generation imaging of cornea," Journal of Biomedical Optics 14(4), 044012 (1 July 2009). https://doi.org/10.1117/1.3183805 . Submission:

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