On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading

Zhijia Yuan; Bai Chen; H. G. Ren; Yingtian Pan

doi:10.1117/1.3223246

1 September 2009 On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading

Zhijia Yuan, Bai Chen, H. G. Ren, Yingtian Pan

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Journal of Biomedical Optics, Vol. 14, Issue 5, 050502 (September 2009). https://doi.org/10.1117/1.3223246

Abstract

It has been recently demonstrated that the cellular details of bladder epithelium embedded in speckle noise can be uncovered with time-lapse ultrahigh-resolution optical coherence tomography (TL-uOCT) by proper time-lapse frame averaging that takes advantage of cellular micromotion in fresh biological tissue ex vivo. Here, spectral-domain 3-D TL-uOCT is reported to further improve the image fidelity, and new experimental evidence is presented to differentiate normal and cancerous nuclei of rodent bladder epithelia. Results of animal cancer study reveal that despite a slight overestimation (e.g., <10%) of nuclear size (DN) to histological evaluation, TL-uOCT is capable of distinguishing normal (D_N7 ≈ μm) and cancerous (e.g., high-grade D_N″13 μm) urothelia, which may potentially be very useful for enhancing the diagnosis of nonpapillary bladder cancer. More animal study is being conducted to examine the utility to differentiate hyperplasia, dysplasia, and carcinoma in situ.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Zhijia Yuan, Bai Chen, H. G. Ren, and Yingtian Pan "On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading," Journal of Biomedical Optics 14(5), 050502 (1 September 2009). https://doi.org/10.1117/1.3223246

Published: 1 September 2009

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