1 September 2009 Photoacoustic tomography of small animal brain with a curved array transducer
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Abstract
We present the application of a curved array photoacoustic tomographic imaging system that can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system is optimized to produce a B-mode, 90-deg field-of-view image at sub-200-μm resolution at a frame rate of ~1 frame/second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-deg scan can be achieved within 15 s. In previous work, two-dimensional (2-D) ex vivo mouse brain cortex imaging has been reported. We report three-dimensional (3-D) small animal brain imaging obtained with the curved array system. The results are presented as a series of 2-D cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Last, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2-D imaging.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Xinmai Yang, Anastasios Maurudis, John K. Gamelin, Andres Aguirre, Quing Zhu, Lihong V. Wang, "Photoacoustic tomography of small animal brain with a curved array transducer," Journal of Biomedical Optics 14(5), 054007 (1 September 2009). https://doi.org/10.1117/1.3227035 . Submission:
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