1 September 2009 Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urology
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Abstract
We present a quantitative near-IR spectroscopy study of the absolute values of oxygen saturation of hemoglobin before and after surgically induced testicular torsion in adult rabbits. Unilateral testicular torsions (0, 540, or 720 deg) on experimental testes and contralateral sham surgery on control testes are performed in four adult rabbits. A specially designed optical probe for measurements at multiple source-detector distances and a commercial frequency-domain tissue spectrometer are used to measure absolute values of testicular hemoglobin saturation. Our results show: (1) a consistent baseline absolute tissue hemoglobin saturation value of 78±5%, (2) a comparable tissue hemoglobin saturation of 77±6% after sham surgery, and (3) a significantly lower tissue hemoglobin saturation of 36±2% after 540- and 720-deg testicular torsion surgery. Our findings demonstrate the feasibility of performing frequency-domain, multidistance near-IR spectroscopy for absolute testicular oximetry in the assessment of testicular torsion. We conclude that near-IR spectroscopy has potential to serve as a clinical diagnostic and monitoring tool for the assessment of absolute testicular hemoglobin desaturation caused by torsion, with the possibility of serving as a complement to conventional color and spectral Doppler ultrasonography.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Bertan Hallacoglu, Bertan Hallacoglu, Richard Matulewicz, Richard Matulewicz, Harriet J. Paltiel, Harriet J. Paltiel, Horacio Padua, Horacio Padua, Patricio Gargollo, Patricio Gargollo, Glenn Cannon, Glenn Cannon, Ahmad Alomari, Ahmad Alomari, Angelo Sassaroli, Angelo Sassaroli, Sergio Fantini, Sergio Fantini, } "Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urology," Journal of Biomedical Optics 14(5), 054027 (1 September 2009). https://doi.org/10.1117/1.3253318 . Submission:
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