1 November 2009 Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis
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Abstract
Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. The ultrasound provides morphological information about the prostate, while the optical system detects and locates fluorophore-marked tumors. A tissue-mimicking phantom, which is representative of prostate tissues both on its optical (absorption μa and diffusion μs) and its ultrasound properties, has been made by our team. A transrectal probe adapted to fluorescence diffuse optical tomography measurements was also developed. Measurements were taken on the prostate phantom with this probe based on a pulsed laser and a time-resolved detection system. A reconstruction algorithm was then used to help locate and quantify fluorescent inclusions of different concentrations at fixed depths.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Jerome Boutet, Lionel Hervé, Mathieu Debourdeau, Laurent Guyon, Philippe Peltie, Jean-Marc Dinten, Laurent Saroul, Francois Duboeuf, Didier Vray, "Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis," Journal of Biomedical Optics 14(6), 064001 (1 November 2009). https://doi.org/10.1117/1.3257236 . Submission:
JOURNAL ARTICLE
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