1 November 2009 Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study
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Abstract
We present for the first time in vivo full three-dimensional (3-D) photoacoustic tomography (PAT) of the distal interphalangeal joint in a human subject. Both absorbed energy density and absorption coefficient images of the joint are quantitatively obtained using our finite-element-based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The results show that major anatomical features in the joint along with the side arteries can be imaged with a 1-MHz transducer in a spherical scanning geometry. In addition, the cartilages associated with the joint can be quantitatively differentiated from the phalanx. This in vivo study suggests that the 3-D PAT method described has the potential to be used for early diagnosis of joint diseases such as osteoarthritis and rheumatoid arthritis.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Yao Sun, Eric S. Sobel, Huabei Jiang, "Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study," Journal of Biomedical Optics 14(6), 064002 (1 November 2009). https://doi.org/10.1117/1.3257246 . Submission:
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