1 November 2009 Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy
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Abstract
We demonstrate a first application, of optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) to breath analysis in a medical environment. Noninvasive monitoring of trace species in exhaled air was performed simultaneous to spirometric measurements on patients at Bichat Hospital (Paris). The high selectivity of the OF-CEAS spectrometer and a time response of 0.3 s (limited by sample flow rate) allowed following the evolution of carbon monoxide and methane concentrations during individual respiratory cycles, and resolving variations among different ventilatory patterns. The minimum detectable absorption on this time scale is about 3×10-10 cm-1. At the working wavelength of the instrument (2.326 μm), this translates to concentration detection limits of ~1 ppbv (45 picomolar, or ~1.25 μg/m3) for CO and 25 ppbv for CH4, well below concentration values found in exhaled air. This same instrument is also able to provide measurement of NH3 concentrations with a detection limit of ~10 ppbv; however, at present, memory effects do not allow its measurement on fast time scales.
© (2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Irene Ventrillard-Courtillot, Irene Ventrillard-Courtillot, Thierry Gonthiez, Thierry Gonthiez, Christine Clerici, Christine Clerici, Daniele Romanini, Daniele Romanini, } "Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy," Journal of Biomedical Optics 14(6), 064026 (1 November 2009). https://doi.org/10.1117/1.3269677 . Submission:
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