1 January 2010 Real-time photoacoustic tomography of cortical hemodynamics in small animals
Author Affiliations +
J. of Biomedical Optics, 15(1), 010509 (2010). doi:10.1117/1.3302807
Abstract
For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.
Changhui Li, Andres Aguirre, John K. Gamelin, Anastasios Maurudis, Quing Zhu, Lihong V. Wang, "Real-time photoacoustic tomography of cortical hemodynamics in small animals," Journal of Biomedical Optics 15(1), 010509 (1 January 2010). http://dx.doi.org/10.1117/1.3302807
Submission: Received ; Accepted
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KEYWORDS
Acquisition tracking and pointing

Photoacoustic tomography

In vivo imaging

Absorption

Ultrasonography

Hemodynamics

Photoacoustic spectroscopy

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