1 January 2010 Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging
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J. of Biomedical Optics, 15(1), 010510 (2010). doi:10.1117/1.3302808
Abstract
We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.
Chulhong Kim, Ruogu Qin, Jeff S. Xu, Lihong V. Wang, Ronald X. Xu, "Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging," Journal of Biomedical Optics 15(1), 010510 (1 January 2010). http://dx.doi.org/10.1117/1.3302808
Submission: Received ; Accepted
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KEYWORDS
Niobium

Tumors

Ultrasonography

Tissues

Photoacoustic spectroscopy

Tissue optics

Breast

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