1 January 2010 Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography
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J. of Biomedical Optics, 15(1), 016017 (2010). doi:10.1117/1.3309455
Abstract
Hamster cheek pouches were exposed to 2-chloroethyl ethyl sulfide [CEES, half-mustard gas (HMG)] at a concentration of 0.4, 2.0, or 5.0 mg/ml for 1 or 5 min. Twenty-four hours post-HMG exposure, tissue damage was assessed by both stereomicrography and optical coherence tomography (OCT). Damage that was not visible on gross visual examination was apparent in the OCT images. Tissue changes were found to be dependent on both HMG concentration and exposure time. The submucosal and muscle layers of the cheek pouch tissue showed the greatest amount of structural alteration. Routine light microscope histology was performed to confirm the OCT observations.
Marie J. Hammer-Wilson, Vi Nguyen, Woonggyu Jung, Yeh-Chan Ahn, Zhongping Chen, Petra B. B. Wilder-Smith, "Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography," Journal of Biomedical Optics 15(1), 016017 (1 January 2010). http://dx.doi.org/10.1117/1.3309455
Submission: Received ; Accepted
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KEYWORDS
Optical coherence tomography

Tissues

Blistering agents

Tissue optics

Lung

Scanning electron microscopy

Visualization

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