1 January 2010 Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring
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J. of Biomedical Optics, 15(1), 017002 (2010). doi:10.1117/1.3290819
Abstract
The development of a real-time, dual-wavelength optical polarimetric system to ultimately probe the aqueous humor glucose concentrations as a means of noninvasive diabetic glucose monitoring is the long-term goal of this research. The key impact of the work is the development of an approach for the reduction of the time-variant corneal birefringence due to motion artifact, which is still a limiting factor preventing the realization of such a device. Our dual-wavelength approach utilizes real-time, closed-loop feedback that employs a classical three-term feedback controller and efficiently reduces the effect of motion artifact that appears as a common noise source for both wavelengths. In vitro results are shown for the open-loop system, and although the dual-wavelength system helps to reduce the noise, it is shown that closed-loop control is necessary to bring the noise down to a sufficient level for physiological monitoring. Specifically, in vitro measurement results with the closed-loop dual-wavelength approach demonstrate a sensitivity of 12.8 mg/dl across the physiologic glucose range in the presence of time-variant test cell birefringence. Overall, it is shown that this polarimetric system has the potential to be used as a noninvasive measure of glucose for diabetes.
Bilal H. Malik, Gerard L. Coté, "Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring," Journal of Biomedical Optics 15(1), 017002 (1 January 2010). http://dx.doi.org/10.1117/1.3290819
Submission: Received ; Accepted
JOURNAL ARTICLE
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KEYWORDS
Glucose

Birefringence

Polarimetry

Control systems

Modulation

Signal detection

Error analysis

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