1 March 2010 Optical phantoms of varying geometry based on thin building blocks with controlled optical properties
Author Affiliations +
J. of Biomedical Optics, 15(2), 025001 (2010). doi:10.1117/1.3369003
Abstract
Current innovations in optical imaging, measurement techniques, and data analysis algorithms express the need for reliable testing and comparison methods. We present the design and characterization of silicone elastomer-based optical phantoms. Absorption is included by adding a green dye and scattering by adding TiO2 or SiO2 particles. Optical coherence tomography measurements demonstrate a linear dependence of the attenuation coefficient with scatterer concentration in the absence of absorbers. Optical transmission spectroscopy of the nonscattering absorbing phantoms shows a linear concentration dependent absorption coefficient. Both types of samples are stable over a period of 6 months. Confocal microscopy of the samples demonstrates a homogeneous distribution of the scatterers, albeit with some clustering. Based on layers with thicknesses as small as 50 μm, we make multifaceted structures resembling flow channels, (wavy) skin-like structures, and a layered and curved phantom resembling the human retina. Finally, we demonstrate the ability to incorporate gold nanoparticles within the phantoms. In conclusion, our phantoms are easy to make, are based on affordable materials, exhibit well-defined and controllable thickness, refractive index, absorption, and scattering coefficients, are homogeneous, and allow the incorporation of novel types of nanoparticle contrast agents. We believe our phantoms fulfill many of the requirements for an "ideal" tissue phantom, and will be particularly suited for novel optical coherence tomography applications.
Daniel Martijn M. de Bruin, Rolf H. Bremmer, Vitali M. Kodach, Roy de Kinkelder, Jan van Marle, Ton G. van Leeuwen, Dirk J. Faber, "Optical phantoms of varying geometry based on thin building blocks with controlled optical properties," Journal of Biomedical Optics 15(2), 025001 (1 March 2010). http://dx.doi.org/10.1117/1.3369003
Submission: Received ; Accepted
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KEYWORDS
Optical coherence tomography

Particles

Nanoparticles

Scattering

Absorption

Signal attenuation

Silicon

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