1 May 2010 Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact
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J. of Biomedical Optics, 15(3), 030510 (2010). doi:10.1117/1.3432654
Abstract
We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ~10 s to complete one 3-D scan of ~2.5×2.5 mm2. The system is sensitive to blood flow with a velocity ranging from ~4 µm/s to ~23 mm/s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.
Yali Jia, Ruikang K. Wang, "Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact," Journal of Biomedical Optics 15(3), 030510 (1 May 2010). http://dx.doi.org/10.1117/1.3432654
Submission: Received ; Accepted
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KEYWORDS
Blood circulation

Capillaries

Imaging systems

Tissue optics

Blood

In vivo imaging

Brain

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