In-vitro retinal model reveals a sharp transition between laser damage mechanisms

Michael L. Denton; Clifton D. Clark; Michael S. Foltz; Kurt J. Schuster; Gary D. Noojin; Larry E. Estlack; Robert J. Thomas

doi:10.1117/1.3449107

1 May 2010 In-vitro retinal model reveals a sharp transition between laser damage mechanisms

Michael L. Denton; Clifton D. Clark; Michael S. Foltz; Kurt J. Schuster; Gary D. Noojin; Larry E. Estlack; Robert J. Thomas

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J. of Biomedical Optics, 15(3), 030512 (2010). doi:10.1117/1.3449107

Abstract

We use laser damage thresholds in an in-vitro retinal model, and computational simulations to examine the laser exposure durations at which damage transitions from photothermal to photochemical at 413 nm. Our results indicate a dramatic shift in 1-h damage thresholds between exposure durations of 60 and 100 s. The trend in our in-vitro results is similar to a trend found in a recent study where retinal lesions were assessed 1-h post laser exposure in the rhesus eye Our data suggest that nonthermal mechanisms did not significantly contribute to cell death, even for exposures of 60 s. Knowledge of the transition point, and lack of concurrent thermal and nonthermal damage processes, are significant for those wishing to devise a comprehensive computational damage model.

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Michael L. Denton, Clifton D. Clark, Michael S. Foltz, Kurt J. Schuster, Gary D. Noojin, Larry E. Estlack, Robert J. Thomas, "In-vitro retinal model reveals a sharp transition between laser damage mechanisms," Journal of Biomedical Optics 15(3), 030512 (1 May 2010). http://dx.doi.org/10.1117/1.3449107

Submission: Received ; Accepted

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