1 May 2010 Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy
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J. of Biomedical Optics, 15(3), 030515 (2010). doi:10.1117/1.3457669
Abstract
We synthesize multifunctional microbubbles (MBs) for targeted delivery of antivascular endothelial growth factor (antiVEGF) therapy with multimodal imaging guidance. Poly-lactic-co-glycolic acid (PLGA) MBs encapsulating Texas Red dye are fabricated by a modified double-emulsion process. Simultaneous ultrasound and fluorescence imaging are achieved using Texas Red encapsulated MBs. The MBs are conjugated with Avastin, an antiVEGF antibody for treating neovascular age-related macular degeneration (AMD). The conjugation efficiency is characterized by enzyme-linked immunosorbent assay (ELISA). The efficiency for targeted binding of Avastin-conjugated MBs is characterized by microscopic imaging. Our work demonstrates the technical potential of using multifunctional MBs for targeted delivery of antiVEGF therapy in the treatment of exudative AMD.
Leilei Zhang, Jeff S. Xu, Virgil E. Sanders, Alan D. Letson, Cynthia J. Roberts, Ronald X. Xu, "Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy," Journal of Biomedical Optics 15(3), 030515 (1 May 2010). http://dx.doi.org/10.1117/1.3457669
Submission: Received ; Accepted
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KEYWORDS
Luminescence

Ultrasonography

Multimodal imaging

Optical coherence tomography

Imaging systems

Scanning electron microscopy

Chlorine

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