1 May 2010 Detection of Plasmodium falciparum-infected red blood cells by optical stretching
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J. of Biomedical Optics, 15(3), 030517 (2010). doi:10.1117/1.3458919
Abstract
We present the application of a microfluidic optical cell stretcher to measure the elasticity of malaria-infected red blood cells. The measurements confirm an increase in host cell rigidity during the maturation of the parasite Plasmodium falciparum. The device combines the selectivity and sensitivity of single-cell elasticity measurements with a throughput that is higher than conventional single-cell techniques. The method has potential to detect early stages of infection with excellent sensitivity and high speed.
Jakob M. A. Mauritz, Teresa Tiffert, Rachel Seear, Franziska Lautenschlaeger, Alessandro Esposito, Virgilio L. Lew, Jochen R. Guck, Clemens F. Kaminski, "Detection of Plasmodium falciparum-infected red blood cells by optical stretching," Journal of Biomedical Optics 15(3), 030517 (1 May 2010). http://dx.doi.org/10.1117/1.3458919
Submission: Received ; Accepted
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KEYWORDS
Blood

Optical fibers

Control systems

Capillaries

Microfluidics

Shape analysis

Optical tweezers

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