1 May 2010 Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
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J. of Biomedical Optics, 15(3), 037004 (2010). doi:10.1117/1.3425884
Abstract
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBFASL-MRI, n=12) cross-validate rCBFDCS against rCBFASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.
Turgut Durduran, Chao Zhou, Erin M. Buckley, Meeri N. Kim, Guoqiang Yu, Regine Choe, J. William Gaynor, Thomas L. Spray, Suzanne M. Durning, Stefanie E. Mason, Lisa M. Montenegro, Susan C. Nicolson, Robert A. Zimmerman, Mary E. Putt, Jiongjiong Wang, Joel H. Greenberg, John A. Detre, Arjun G. Yodh, Daniel J. Licht, "Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects," Journal of Biomedical Optics 15(3), 037004 (1 May 2010). http://dx.doi.org/10.1117/1.3425884
Submission: Received ; Accepted
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KEYWORDS
Near infrared spectroscopy

Oxygen

Hemodynamics

Magnetic resonance imaging

Mode conditioning cables

Carbon monoxide

Optical testing

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