1 July 2010 Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina
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J. of Biomedical Optics, 15(4), 040506 (2010). doi:10.1117/1.3475489
Abstract
A combined ultrahigh resolution optical coherence tomography (UHROCT) and a electroretinography (ERG) system is presented for simultaneous imaging of the retinal structure and physiological response to light stimulation in the rodent eye. The 1060-nm UHROCT system provides ~3×5 µm (axial×lateral) resolution in the rat retina and time resolution of 22 µs. A custom-designed light stimulator integrated into the UHROCT imaging probe provides light stimuli with user-selected color, duration, and intensity. The performance of the combined system is demonstrated in vivo in healthy rats, and in a rat model of drug-induced outer retinal degeneration. Experimental results show correlation between the observed structural and physiological changes in the healthy and degenerated retina.
Alireza Akhlagh Moayed, Sepideh Hariri, Chulho Hyun, Bruce Doran, Timothy W. Kraft, Shelley Boyd, Kostadinka K. Bizheva, "Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina," Journal of Biomedical Optics 15(4), 040506 (1 July 2010). http://dx.doi.org/10.1117/1.3475489
Submission: Received ; Accepted
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KEYWORDS
Retina

Imaging systems

In vivo imaging

Optical coherence tomography

Reflectivity

Eye

Functional imaging

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