1 July 2010 In vivo functional retinal optical coherence tomography
Author Affiliations +
J. of Biomedical Optics, 15(4), 041513 (2010). doi:10.1117/1.3463008
Abstract
An experimental design for noninvasive assessment of neural retinal tissue function with enhanced sensitivity is presented. By matching the response detection to a defined flicker frequency stimulus similar to heterodyne detection, the response signal will be shifted out of the low-frequency noise and the specificity of response detection will be strongly enhanced. Optimal measurement parameters are discussed, such as the function and timing of the response function to a single flash stimulus. The results indicate responses on the order of 200 ms that have been probed with our frequency-encoded approach using 5 Hz flickering. Preliminary results indicate the feasibility of our measurement concept to assess small changes in reflectivity with enhanced sensitivity. A functional tomogram for response localization and quantification is introduced.
Tilman Schmoll, Christoph Kolbitsch, Rainer A. Leitgeb, "In vivo functional retinal optical coherence tomography," Journal of Biomedical Optics 15(4), 041513 (1 July 2010). http://dx.doi.org/10.1117/1.3463008
Submission: Received ; Accepted
JOURNAL ARTICLE
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KEYWORDS
Retina

Optical coherence tomography

In vivo imaging

Signal to noise ratio

Eye

Reflectivity

Signal detection

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