1 November 2010 Fiber-optic nonlinear endomicroscopy with focus scanning by using shape memory alloy actuation
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J. of Biomedical Optics, 15(6), 060506 (2010). doi:10.1117/1.3523234
Abstract
A miniature fiber optic endomicroscope with built-in dynamic focus scanning capability is developed for the first time for 3-D two-photon fluorescence (TPF) imaging of biological samples. Fast 2-D lateral beam scanning is realized by resonantly vibrating a double-clad fiber cantilever with a tubular piezoactuator. Slow axial scanning is achieved by moving the distal end of the imaging probe with an extremely compact electrically driven shape memory alloy (SMA). The 10-mm-long SMA allows 150-μm contractions with a driving voltage varying only from 50 to 100 mV. The response of the SMA contraction with the applied voltage is nonlinear, but repeatable and can be accurately calibrated. Depth-resolved imaging of acriflavine-stained biological tissues and unstained white paper with the endomicroscope is performed, and the results demonstrate the feasibility of 3-D nonlinear optical imaging with the SMA-based scanning fiber-optic endomicroscope.
Yicong Wu, Yuying Zhang, Jiefeng Xi, Ming-Jun Li, Xingde Li, "Fiber-optic nonlinear endomicroscopy with focus scanning by using shape memory alloy actuation," Journal of Biomedical Optics 15(6), 060506 (1 November 2010). http://dx.doi.org/10.1117/1.3523234
Submission: Received ; Accepted
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KEYWORDS
Shape memory alloys

Fiber optics

Scanners

Imaging systems

Tissues

Luminescence

Calibration

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