1 January 2010 Fluorescence imaging of vascular endothelial growth factor in tumors for mice embedded in a turbid medium
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Abstract
We demonstrate the feasibility of fluorescence imaging of deeply seated tumors using mice injected with an angiogenesis tracer, a vascular endothelial growth factor conjugated with the infrared dye cyanine 7 (VEGF/Cy7). Our optical-only imaging reconstruction method separately estimates the target depth, and then applies this information to reconstruct functional information such as fluorophore concentration. Fluorescence targets with concentrations as low as sub-25 nM are well reconstructed at depths up to 2 cm in both homogeneous and heterogeneous media with this technique.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Nrusingh C. Biswal, Nrusingh C. Biswal, John K. Gamelin, John K. Gamelin, Baohong Yuan, Baohong Yuan, Marina V. Backer, Marina V. Backer, Joseph M. Backer, Joseph M. Backer, Quing Zhu, Quing Zhu, } "Fluorescence imaging of vascular endothelial growth factor in tumors for mice embedded in a turbid medium," Journal of Biomedical Optics 15(1), 016012 (1 January 2010). https://doi.org/10.1117/1.3306704 . Submission:
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