1 March 2010 Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo
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J. of Biomedical Optics, 15(2), 021303 (2010). doi:10.1117/1.3333545
With a refined ultrasound-array-based real-time photoacoustic microscopy (UA-PAM) system, we demonstrate the feasibility of noninvasive in vivo imaging of human pulsatile dynamics. The system, capable of real-time B-scan imaging at 50 Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans. After the validation, a human artery around the palm-wrist area is imaged, and its pulsatile dynamics, including the arterial pulsatile motion and changes in hemoglobin concentration, is monitored with 20-ms B-scan imaging temporal resolution. To our knowledge, this is the first demonstration of real-time photoacoustic imaging of human physiological dynamics. Our results show that UA-PAM can potentially enable many new possibilities for studying functional and physiological dynamics in both preclinical and clinical imaging settings.
Liang Song, Konstantin I. Maslov, K. Kirk Shung, Lihong V. Wang, "Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo," Journal of Biomedical Optics 15(2), 021303 (1 March 2010). https://doi.org/10.1117/1.3333545

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