1 March 2010 Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo
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With a refined ultrasound-array-based real-time photoacoustic microscopy (UA-PAM) system, we demonstrate the feasibility of noninvasive in vivo imaging of human pulsatile dynamics. The system, capable of real-time B-scan imaging at 50 Hz and high-speed 3-D imaging, is validated by imaging the subcutaneous microvasculature in rats and humans. After the validation, a human artery around the palm-wrist area is imaged, and its pulsatile dynamics, including the arterial pulsatile motion and changes in hemoglobin concentration, is monitored with 20-ms B-scan imaging temporal resolution. To our knowledge, this is the first demonstration of real-time photoacoustic imaging of human physiological dynamics. Our results show that UA-PAM can potentially enable many new possibilities for studying functional and physiological dynamics in both preclinical and clinical imaging settings.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Liang Song, Liang Song, Konstantin I. Maslov, Konstantin I. Maslov, K. Kirk Shung, K. Kirk Shung, Lihong V. Wang, Lihong V. Wang, } "Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo," Journal of Biomedical Optics 15(2), 021303 (1 March 2010). https://doi.org/10.1117/1.3333545 . Submission:

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