1 March 2010 Multispectral in vivo three-dimensional optical coherence tomography of human skin
Author Affiliations +
Abstract
The capability of optical coherence tomography (OCT) to perform "optical biopsy" of tissues within a depth range of 1 to 2 mm with micron-scale resolution in real time makes it a promising biomedical imaging modality for dermatologic applications. Three high-speed, spectrometer-based frequency-domain OCT systems operating at 800 nm (20,000 A-scans/s), 1060 nm, and 1300 nm (both 47,000 A-scans/s) at comparable signal-to-noise ratio (SNR), SNR roll-off with scanning depth, and transverse resolution (<15 µm) were used to acquire 3-D tomograms of glabrous and hairy human skin in vivo. Images obtained using these three systems were compared in terms of penetration depth, resolution, and contrast. Normal as well as abnormal sites like moles and scar tissue were examined. In this preliminary study, skin pigmentation had little effect on penetration accomplished at three different wavelengths. The epidermis and dermal-epidermal junction could be properly delineated using OCT at 800 nm, and this wavelength offered better contrast over the other two wavelength regions. OCT at 1300 nm permits imaging of deeper dermal layers, critical for detecting deeper tumor boundaries and other deeper skin pathologies. The performance at 1060 nm compromises between the other wavelengths in terms of penetration depth and image contrast.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Alex Aneesh, Alex Aneesh, Boris Považay, Boris Považay, Bernd Hofer, Bernd Hofer, Sergei V. Popov, Sergei V. Popov, Carl Glittenberg, Carl Glittenberg, Susanne Binder, Susanne Binder, Wolfgang Drexler, Wolfgang Drexler, } "Multispectral in vivo three-dimensional optical coherence tomography of human skin," Journal of Biomedical Optics 15(2), 026025 (1 March 2010). https://doi.org/10.1117/1.3400665 . Submission:
JOURNAL ARTICLE
15 PAGES


SHARE
RELATED CONTENT

Wide field OCT imaging of oral lesions in vivo ...
Proceedings of SPIE (January 01 1900)
OCT imaging of cardiac architecture
Proceedings of SPIE (June 30 2004)
3D OCT images from retina and skin
Proceedings of SPIE (December 14 2000)

Back to Top