1 March 2010 Blood screening using diffraction phase cytometry
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Abstract
advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensible tools for physicians and researchers alike, they provide limited information on the detailed morphology of individual cells, and merely alert the operator to manually examine a blood smear by raising flags when abnormalities are detected. We demonstrate an automatic interferometry-based smear analysis technique known as diffraction phase cytometry (DPC), which is capable of providing the same information on red blood cells as is provided by current clinical analyzers, while rendering additional, currently unavailable parameters on the 2-D and 3-D morphology of individual red blood cells. To validate the utility of our technique in a clinical setting, we present a comparison between tests generated from 32 patients by a state of the art clinical impedance counter and DPC.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Mustafa Mir, Mustafa Mir, Huafeng Ding, Huafeng Ding, Zhuo Wang, Zhuo Wang, Krishnarao Tangella, Krishnarao Tangella, Gabriel Popescu, Gabriel Popescu, } "Blood screening using diffraction phase cytometry," Journal of Biomedical Optics 15(2), 027016 (1 March 2010). https://doi.org/10.1117/1.3369965 . Submission:
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