1 July 2010 Growth of melanoma brain tumors monitored by photoacoustic microscopy
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Abstract
Melanoma is a primary malignancy that is known to metastasize to the brain and often causes death. The ability to image the growth of brain melanoma in vivo can provide new insights into its evolution and response to therapies. In our study, we use a reflection mode photoacoustic microscopy (PAM) system to detect the growth of melanoma brain tumor in a small animal model. The melanoma tumor cells are implanted in the brain of a mouse at the beginning of the test. Then, PAM is used to scan the region of implantation in the mouse brain, and the growth of the melanoma is monitored until the death of the animal. It is demonstrated that PAM is capable of detecting and monitoring the brain melanoma growth noninvasively in vivo.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Jacob Staley, Patrick Grogan, Abbas K. Samadi, Huizhong Cui, Mark S. Cohen, Xinmai Yang, "Growth of melanoma brain tumors monitored by photoacoustic microscopy," Journal of Biomedical Optics 15(4), 040510 (1 July 2010). https://doi.org/10.1117/1.3478309 . Submission:
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