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1 July 2010 In vivo functional retinal optical coherence tomography
Tilman Schmoll, Christoph Kolbitsch, Rainer A. Leitgeb
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Journal of Biomedical Optics, Vol. 15, Issue 4, 041513 (July 2010). https://doi.org/10.1117/1.3463008
Abstract
An experimental design for noninvasive assessment of neural retinal tissue function with enhanced sensitivity is presented. By matching the response detection to a defined flicker frequency stimulus similar to heterodyne detection, the response signal will be shifted out of the low-frequency noise and the specificity of response detection will be strongly enhanced. Optimal measurement parameters are discussed, such as the function and timing of the response function to a single flash stimulus. The results indicate responses on the order of 200 ms that have been probed with our frequency-encoded approach using 5 Hz flickering. Preliminary results indicate the feasibility of our measurement concept to assess small changes in reflectivity with enhanced sensitivity. A functional tomogram for response localization and quantification is introduced.
©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Tilman Schmoll, Christoph Kolbitsch, and Rainer A. Leitgeb "In vivo functional retinal optical coherence tomography," Journal of Biomedical Optics 15(4), 041513 (1 July 2010). https://doi.org/10.1117/1.3463008
Published: 1 July 2010
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Cited by 31 scholarly publications and 2 patents.
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KEYWORDS
Retina
Optical coherence tomography
In vivo imaging
Signal to noise ratio
Eye
Reflectivity
Signal detection
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