CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 15 > Issue 5 > Article
Open Access
1 September 2010 Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy
Anju M. Raja, Shuoyu Xu, Wanxin Sun, Jianbiao Zhou, Dean C. S. Tai, Chien-Shing Chen, Jagath C. Rajapakse, Peter T. C. So, Hanry Yu
Author Affiliations +
Journal of Biomedical Optics, Vol. 15, Issue 5, 056016 (September 2010). https://doi.org/10.1117/1.3497565
Abstract
Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers.
©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Anju M. Raja, Shuoyu Xu, Wanxin Sun, Jianbiao Zhou, Dean C. S. Tai, Chien-Shing Chen, Jagath C. Rajapakse, Peter T. C. So, and Hanry Yu "Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy," Journal of Biomedical Optics 15(5), 056016 (1 September 2010). https://doi.org/10.1117/1.3497565
Published: 1 September 2010
JOURNAL ARTICLE
 11 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 12 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Collagen
Tumors
Scanning helium ion microscopy
Microscopes
Second-harmonic generation
Signal to noise ratio
Visualization
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top