Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method

Subhadra Srinivasan; Colin M. Carpenter; Hamid R. Ghadyani; Senate J. Taka; Peter A. Kaufman; Roberta M. diFlorio-Alexander; Wendy A. Wells; Brian W. Pogue; Keith D. Paulsen

doi:10.1117/1.3499419

1 November 2010 Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method

Subhadra Srinivasan, Colin M. Carpenter, Hamid R. Ghadyani, Senate J. Taka, Peter A. Kaufman, Roberta M. diFlorio-Alexander, Wendy A. Wells, Brian W. Pogue, Keith D. Paulsen

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Journal of Biomedical Optics, Vol. 15, Issue 6, 061703 (November 2010). https://doi.org/10.1117/1.3499419

Abstract

We demonstrate quantitative functional imaging using image-guided near-infrared spectroscopy (IG-NIRS) implemented with the boundary element method (BEM) for reconstructing 3-D optical property estimates in breast tissue in vivo. A multimodality MRI-NIR system was used to collect measurements of light reflectance from breast tissue. The BEM was used to model light propagation in 3-D based only on surface discretization in order to reconstruct quantitative values of total hemoglobin (HbT), oxygen saturation, water, and scatter. The technique was validated in experimental measurements from heterogeneous breast-shaped phantoms with known values and applied to a total of seven subjects comprising six healthy individuals and one participant with cancer imaged at two time points during neoadjuvant chemotherapy. Using experimental measurements from a heterogeneous breast phantom, BEM for IG-NIRS produced accurate values for HbT in the inclusion with a <3% error. Healthy breast tissues showed higher HbT and water in fibroglandular tissue than in adipose tissue. In a subject with cancer, the tumor showed higher HbT compared to the background. HbT in the tumor was reduced by 9 µM during treatment. We conclude that 3-D MRI-NIRS with BEM provides quantitative and functional characterization of breast tissue in vivo through measurement of hemoglobin content. The method provides potentially complementary information to DCE-MRI for tumor characterization.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Subhadra Srinivasan, Colin M. Carpenter, Hamid R. Ghadyani, Senate J. Taka, Peter A. Kaufman, Roberta M. diFlorio-Alexander, Wendy A. Wells, Brian W. Pogue, and Keith D. Paulsen "Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method," Journal of Biomedical Optics 15(6), 061703 (1 November 2010). https://doi.org/10.1117/1.3499419

Published: 1 November 2010

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