1 November 2010 Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging
Author Affiliations +
Abstract
Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screening/diagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early stage murine pancreatic tumors that could not be identified by blinded, skilled observers using MRI alone, were easily identified with MRI along with FI images acquired with photomultiplier tube detection and offset laser scanning. Moreover, we show that fluorescence lifetime (FLT) imaging enables positive identification of the labeling fluorophore and discriminates it from surrounding tissue autofluorescence. Our data suggest combined-modality imaging with MRI, FI, and FLT can be used to screen and diagnose early tumors.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Ahmet Erten, Ahmet Erten, David J. Hall, David J. Hall, Carl K. Hoh, Carl K. Hoh, Hop S. Tran Cao, Hop S. Tran Cao, Sharmeela Kaushal, Sharmeela Kaushal, Sadik C. Esener, Sadik C. Esener, Robert M. Hoffman, Robert M. Hoffman, Michael Bouvet, Michael Bouvet, James Chen, James Chen, Santosh Kesari, Santosh Kesari, Milan T. Makale, Milan T. Makale, } "Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging," Journal of Biomedical Optics 15(6), 066012 (1 November 2010). https://doi.org/10.1117/1.3509111 . Submission:
JOURNAL ARTICLE
6 PAGES


SHARE
Back to Top