1 February 2011 Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy
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J. of Biomedical Optics, 16(2), 021110 (2011). doi:10.1117/1.3533313
Abstract
We demonstrate for the first time the applicability of multimodal nonlinear optical (NLO) microscopy to the interrogation of stented coronary arteries under different diet and stent deployment conditions. Bare metal stents and Taxus drug-eluting stents (DES) were placed in coronary arteries of Ossabaw pigs of control and atherogenic diet groups. Multimodal NLO imaging was performed to inspect changes in arterial structures and compositions after stenting. Sum frequency generation, one of the multimodalities, was used for the quantitative analysis of collagen content in the peristent and in-stent artery segments of both pig groups. Atherogenic diet increased lipid and collagen in peristent segments. In-stent segments showed decreased collagen expression in neointima compared to media. Deployment of DES in atheromatous arteries inhibited collagen expression in the arterial media.
Han-Wei Wang, Ji-Xin Cheng, Michael Sturek, Vlad V. Simianu, Matthew J. Locker, "Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy," Journal of Biomedical Optics 16(2), 021110 (1 February 2011). http://dx.doi.org/10.1117/1.3533313
Submission: Received ; Accepted
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KEYWORDS
Collagen

Arteries

Nonlinear optics

Image segmentation

Microscopy

Optical microscopy

Visualization

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