1 February 2011 Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications
Author Affiliations +
J. of Biomedical Optics, 16(2), 025002 (2011). doi:10.1117/1.3533321
Abstract
This work describes a novel process for the fabrication of hybrid nanostructured particles showing intense tunable photoluminescence and a simultaneous ferromagnetic behavior. The fabrication process involves the synthesis of nanostructured porous silicon (NPSi) by chemical anodization of crystalline silicon and subsequent in pore growth of Co nanoparticles by electrochemically-assisted infiltration. Final particles are obtained by subsequent sonication of the Co-infiltrated NPSi layers and conjugation with poly(ethylene glycol) aiming at enhancing their hydrophilic character. These particles respond to magnetic fields, emit light in the visible when excited in the UV range, and internalize into human mesenchymal stem cells with no apoptosis induction. Furthermore, cytotoxicity in in-vitro systems confirms their biocompatibility and the viability of the cells after incorporation of the particles. The hybrid nanostructured particles might represent powerful research tools as cellular trackers or in cellular therapy since they allow combining two or more properties into a single particle.
Alvaro Muñoz-Noval, Vanessa Sanchez-Vaquero, Vicente Torres-Costa, Darío Gallach, Miguel Manso-Silván, Josefa P. Garcia-Ruiz, Raúl J. Martín-Palma, Vicente Ferro-Llanos, Jose Javier Serrano, Francisco del Pozo, "Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications," Journal of Biomedical Optics 16(2), 025002 (1 February 2011). http://dx.doi.org/10.1117/1.3533321
Submission: Received ; Accepted
JOURNAL ARTICLE
8 PAGES


SHARE
KEYWORDS
Particles

Silicon

Nanostructuring

Luminescence

Nanoparticles

Magnetism

Atmospheric particles

Back to Top