1 February 2011 Comparison of spectroscopically measured finger and forearm tissue ethanol concentration to blood and breath ethanol measurements
Author Affiliations +
J. of Biomedical Optics, 16(2), 028003 (2011). doi:10.1117/1.3535594
Abstract
Previous works investigated a spectroscopic technique that offered a promising alternative to blood and breath assays for determining in vivo alcohol concentration. Although these prior works measured the dorsal forearm, we report the results of a 26-subject clinical study designed to evaluate the spectroscopic technique at a finger measurement site through comparison to contemporaneous forearm spectroscopic, venous blood, and breath measurements. Through both Monte Carlo simulation and experimental data, it is shown that tissue optical probe design has a substantial impact on the effective path-length of photons through the skin and the signal-to-noise ratio of the spectroscopic measurements. Comparison of the breath, blood, and tissue assays demonstrated significant differences in alcohol concentration that are attributable to both assay accuracy and alcohol pharmacokinetics. Similar to past works, a first order kinetic model is used to estimate the fraction of concentration variance explained by alcohol pharmacokinetics (72.6-86.7%). A significant outcome of this work was significantly improved pharmacokinetic agreement with breath (arterial) alcohol of the finger measurement (mean kArt-Fin = 0.111 min−1) relative to the forearm measurement (mean kArt-For = 0.019 min−1) that is likely due to the increased blood perfusion of the finger.
Trent Ridder, Benjamin J. Ver Steeg, Bentley D. Laaksonen, Edward L. Hull, "Comparison of spectroscopically measured finger and forearm tissue ethanol concentration to blood and breath ethanol measurements," Journal of Biomedical Optics 16(2), 028003 (1 February 2011). http://dx.doi.org/10.1117/1.3535594
Submission: Received ; Accepted
JOURNAL ARTICLE
12 PAGES


SHARE
KEYWORDS
Tissue optics

Blood

Tissues

Spectroscopy

Optical design

Photons

Bioalcohols

Back to Top